Vertebral Augmentation: Vertebroplasty, Kyphoplasty, Cementoplasty

Dr Suresh Babu
Senior Consultant Vascular and Interventional Radiologist

Vertebral augmentation procedures help restore vertebral body strength and stability after compression fractures or bone damage. These minimally invasive techniques involve injecting bone cement into damaged vertebrae to provide structural support and pain relief. The three main procedures—vertebroplasty, kyphoplasty, and cementoplasty—share common objectives but differ in their specific approaches and applications.

What is Vertebral Augmentation?

Vertebral augmentation encompasses several procedures designed to treat vertebral compression fractures (VCFs). These fractures typically occur when the vertebral body collapses, most often due to:

Osteoporosis

A condition causing decreased bone density and increased fracture risk. Osteoporosis weakens the vertebrae, making them susceptible to compression fractures even during routine activities like bending or lifting.

Spinal tumours

Both primary and metastatic tumours can weaken vertebral bodies. Tumours may destroy bone tissue or disrupt normal bone architecture, leading to structural instability and fractures.

Traumatic injury

High-impact forces can cause acute vertebral compression fractures in patients of any age. These injuries often result from falls, motor vehicle accidents, or sports-related incidents.

VCFs often cause significant back pain, reduced mobility, and in some cases, progressive spinal deformity. Vertebral augmentation procedures aim to stabilise these fractures, reduce pain, and prevent further vertebral collapse.

Indications for Vertebral Augmentation

Vertebral augmentation procedures are considered in the following situations:

Patients experiencing ongoing pain despite analgesics, rest, and bracing may benefit from vertebral augmentation. These procedures offer an intermediate option between continued conservative care and major spinal surgery.

Recent compression fractures (generally less than 6-8 weeks old) typically respond best to vertebral augmentation. The timing allows intervention before the fracture fully heals in a collapsed position.

The pain pattern should match the anatomical location of the identified fracture. Consistency between symptoms and imaging findings aids in predicting successful outcomes.

Benefits of Vertebral Augmentation

Vertebral augmentation procedures offer several potential benefits:

Pain relief

Most patients report significant reduction in pain levels. This analgesic effect typically begins within days of the procedure and continues long-term for many patients.

Improved mobility

Reduced pain allows increased physical activity. Improved mobility helps prevent deconditioning and secondary complications associated with prolonged immobility.

Reduced medication needs

Many patients require fewer pain medications after the procedure. Decreased opioid requirements reduce medication-related side effects and dependency risks.

Vertebral stabilisation

Cement augmentation prevents further vertebral collapse. This stabilisation helps maintain spinal alignment and potentially reduces adjacent segment fracture risks.

Types of Vertebral Augmentation Procedures

Vertebroplasty involves the direct injection of bone cement (typically polymethylmethacrylate or PMMA) into the fractured vertebra. The procedure follows these steps:

  • Imaging guidance: Fluoroscopy (real-time X-ray) is used to visualise the vertebra and guide the needle accurately to the fracture site. This continuous imaging allows for precise needle placement and cement delivery.
  • Local anaesthesia: The procedure typically requires only local anaesthesia and conscious sedation. The injection site is numbed while the patient remains awake but relaxed during the procedure.
  • Cement injection: Bone cement is injected directly into the fractured vertebra. The cement flows into the spaces within the damaged bone and hardens within minutes, providing immediate structural support.

 

Vertebroplasty aims to stabilise the fracture, prevent further collapse, and provide prompt pain relief. The procedure usually takes less than an hour per treated vertebra and often allows patients to return home the same day.

Kyphoplasty builds upon the vertebroplasty technique by adding a step to create space within the collapsed vertebra.

  • Balloon inflation: After needle placement into the vertebra, a special balloon is inserted and inflated. This creates a cavity within the compressed vertebra and can partially restore vertebral height. The balloon expansion helps create a well-defined space for cement placement.
  • Controlled cement delivery: After removing the balloon, bone cement is injected into the cavity. The predefined space allows for more controlled cement distribution compared to vertebroplasty. This controlled delivery potentially reduces cement leakage risks.
  • Height restoration: Unlike vertebroplasty, kyphoplasty may partially restore vertebral height and reduce kyphotic deformity (forward curvature of the spine). This height restoration can help improve spinal alignment in some patients.

 

Kyphoplasty typically takes longer than vertebroplasty due to the additional balloon inflation step, but shares similar recovery times and pain relief outcomes.

Cementoplasty refers to bone cement injection into bones other than vertebrae or for conditions beyond simple compression fractures.

  • Tumour management: Cementoplasty often treats bone tumours or metastases throughout the skeleton. The cement provides structural support to bones weakened by tumour invasion and may help reduce pain associated with these lesions.
  • Preventive application: In some cases, cementoplasty may be performed preventively on bones at high risk of fracture due to significant tumour involvement. This prophylactic approach aims to strengthen compromised bones before fractures occur.
  • Combined therapy: Cementoplasty may be combined with tumour ablation techniques (such as radiofrequency ablation) to provide both tumour treatment and structural support in a single procedure. This combined approach addresses both the tumour and its structural consequences.
    While sharing basic principles with vertebroplasty, cementoplasty adapts the technique to different anatomical locations and clinical scenarios.

Preparing for the Procedure

Imaging evaluation

MRI, CT scans, or bone scans are used to determine the location, age, and characteristics of vertebral fractures. Imaging performed within 2-4 weeks prior to the procedure provides the most accurate assessment of current bone status, including signs of edema or ongoing fracture healing.

Laboratory testing

Blood tests assess coagulation status and rule out infection. Complete blood count, renal function tests, and coagulation profiles help ensure the patient can safely undergo the procedure.

Medication review

Certain medications may need to be temporarily discontinued. Anticoagulants, some anti-inflammatory drugs, and certain other medications may require adjustment before the procedure to reduce bleeding risks.

Step-by-Step Procedure

Most procedures use local anaesthesia with conscious sedation. This approach keeps the patient comfortable while allowing them to respond to questions during the procedure.

Using fluoroscopic guidance, the specialist inserts a needle through the skin into the vertebral body. The transpedicular approach (through the pedicle of the vertebra) or parapedicular approach (alongside the pedicle) provides access to the vertebral body.

Bone cement is prepared and injected. The cement’s consistency and injection timing are carefully controlled to allow proper flow while minimising leakage risks.

Continuous fluoroscopic imaging monitors cement distribution. Real-time monitoring allows immediate detection of potential cement leakage or suboptimal distribution.

The entire procedure typically takes 30-90 minutes, depending on the number of vertebrae treated and whether kyphoplasty is performed.

Post-procedure Care and Recovery

  • Observation period: Patients remain under observation for 1-3 hours. This monitoring period ensures that there are no immediate complications prior to discharge.
  • Activity guidelines: Normal activities can usually resume gradually. Most patients can return to light activities within days, with full recovery expected within 4-6 weeks.
  • Follow-up imaging: X-rays confirm cement placement and assess vertebral stability. These images provide baseline documentation of the treatment result for comparison during future follow-up evaluations.

Potential Risks and Complications

Vertebral augmentation carries several potential risks and complications. These include cement leakage outside the vertebral body, which is often asymptomatic but can occasionally affect nearby nerves or blood vessels. There is a risk of adjacent vertebral fractures due to altered biomechanics, infection at the procedure site, and allergic reactions to the bone cement or contrast materials. While serious complications are rare, the risk increases in patients with complex fractures, severe osteoporosis, or multiple underlying medical conditions.

Dr Suresh Babu

Dr Suresh Babu

Senior Consultant Vascular and Interventional Radiologist

Dr Suresh is one of the leading specialists in vascular and non-vascular radiological interventions, interventional oncology, pain relief in interventional radiology and neuro interventional procedures in Singapore and Southeast Asia.

  • MBBS (Madras)
  • DMRD (Liverpool)
  • FRCP (Dublin)
  • FRCR (London)
  • FCIRSE (Europe)
  • EBIR (Europe)
  • MBA (Birmingham)

His training includes comprehensive programmes in Radiology and Interventional Radiology in the UK and Canada, equipping him with the skills to manage even the most complex procedures.

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    Vertebral Augmentation: Vertebroplasty, Kyphoplasty, Cementoplasty

    Frequently Asked
    Questions

    How long does bone cement take to harden during vertebral augmentation?

    The bone cement used in vertebral augmentation procedures typically begins hardening within 2-3 minutes after injection and reaches full hardness within 10-15 minutes. This rapid solidification allows immediate structural support to the fractured vertebra and contributes to the prompt pain relief many patients experience.

    Can vertebral augmentation procedures be repeated if new fractures develop?

    Yes, vertebral augmentation can be performed multiple times if different vertebrae develop fractures. There is no specific limit to the number of procedures a patient can undergo, though each case requires individual assessment. The decision depends on the patient’s overall bone quality, response to previous procedures, and specific fracture characteristics.

    How does the bone cement interface with natural bone over time?

    The bone cement (PMMA) used in vertebral augmentation does not integrate with natural bone tissue. Instead, it remains as a permanent implant that provides mechanical support. The body forms a thin fibrous layer around the cement, creating a stable interface. This permanent presence does not typically cause long-term problems but means the cement will appear unchanged on future imaging studies.